Veterinary chemotherapy drugs

Anemia (low red blood cell count) is often a complication of cancer but is rarely caused by the chemotherapy drugs used in veterinary medicine. Hair Loss. Hair follicle cells in dogs (and cats) that are wire-haired or non-shedding may be particularly susceptible to chemotherapy. Certain breeds of dogs, such as terriers and poodles, will. Chemotherapy drugs (chemo) are compounds that kill fast-growing cancer cells. They may be administered intravenously (IV), by subcutaneous (under the skin) or intramuscular (IM) injection, or orally. Traditional chemotherapy drugs work by damaging cellular processes so that cancer cells cannot grow and divide, eventually killing them The goal of veterinary oncology is to provide for the medical and non-medical needs of the cancer patient and the client, and improve the quality of life for both. Educating and protecting the patient, client, hospital staff, and yourself are quality steps toward that goal. Safe handling of chemotherapy drugs. American College of Veterinary. Chemotherapy is the therapeutic use of chemical agents to destroy, or inhibit the growth and division of cancer cells. Chemotherapy is usually used when tumors are widespread or when there is significant or immediate risk of spread from the primary location. It is often used following the surgical removal of tumors. In some cases, chemotherapy is started prior to surgery Chemotherapy safety in veterinary . practice: Hazardous Drug Preparation. Comp Cont Educ Pract Vet . 24:140-146. Mader RM, Rizovski B, Steger GG, Wachter A, Kotz R, Rainer H [1996] Exposure of oncologic nurses to methotrexate in the . treatment of osteosarcoma. Arch Environ Health . 51:310-314. Mair TS, Couto CG [2006]. The use of cytotoxic.

Cordes, for his part, left veterinary practice for nearly a decade after developing cancer. I was afraid of veterinary clinics after a while, the chemical smells, the radiology, the breathing of fumes, the anesthetics, the chemotherapy, all the drugs, all the different hazards When giving IV injections of chemotherapy, it is critical to use a cleanly placed (only one venipuncture attempt) indwelling IV catheter. Drugs such as vincristine, vinblastine, and doxorubicin (Adriamycin) among others are vesicants. Perivascular administration may result in severe local reaction and tissue slough Chemotherapy handling and administration to veterinary patients puts healthcare personnel at risk of chemotherapy exposure. Environmental exposure to even low levels of chemotherapy agents can lead to an increased risk of reproductive failure and cancer development

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Ryan Veterinary Hospital of the University of Pennsylvania The diagnosis of cancer is stressful for pet owners, and the prospect of chemotherapy treatments can be equally difficult. Many owners are rightfully concerned about potential side effects of chemotherapy, and certain treatments can be costly and involve multiple visits to the hospital. Most drugs used in veterinary practice do not pose a major hazard to the person handling them or handling an animal treated with them (or its waste). Chemotherapeutic agents are the exception. People who are exposed to these drugs during their use in animals risk serious side effects. In addition, chemotherapeutic agents pose a serious risk to patient welfare if not used correctly Common Chemotherapy Drugs I often receive questions from both concerned clients and veterinarians about the drugs which are being used in a patient's treatment protocol. Veterinary oncologists use many different anti-neoplastic agents. These agents include chemotherapy drugs, growth inhibitors and immunotherapy Hematuria (bloody urine): One of the chemotherapy drugs that we use [Cytoxan (cyclophosphamide)] may occasionally cause hematuria (bloody urine) in dogs. If this occurs, you should discontinue the medication immediately and contact us for treatment. This side effect is specific to Cytoxan (cyclophosphamide)

Chemotherapy (anticancer drugs) is frequently used to control some types of cancer in pets and can be employed alone or in addition to other types of treatments such as surgery or radiation therapy. It may be given orally (pills), intravenously or directly into the tumor The chemotherapy drugs used to treat an animal may come in either an injection or pill form. Your veterinarian will review the administration procedures relative to your pet's protocol and will also inform you if any other procedures such as placement of a vascular access port (VAP) or the use of sedation is required For example, when a veterinary healthcare worker has to prepare the chemotherapy drug Mustargen® for a treatment, they wear a disposable gown, respirator, and gloves, says Dr. Hirst. For other drugs like vincristine, the veterinary healthcare worker will wear only a disposable gown and gloves

An Overview of Commonly Used Chemotherapy Drugs

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The introduction of anti-CD20 monoclonal antibodies in human oncology has revolutionized the treatment of B-cell lymphoma with significantly improved outcomes versus chemotherapy alone. In veterinary medicine, anti-CD20 and anti-CD52 monoclonal antibodies have received either USDA or conditional approval to treat canine B-cell and T-cell. Certain cancers are regarded to be very sensitive to chemotherapy, others are less so and there are tumours that do not appear to respond to current veterinary chemotherapy drugs at all. All patients receiving chemotherapy are potentially at risk of developing side effects and therefore health assessments need to be made prior to calculation of. After initiating a chemotherapy protocol for a patient, most oncology departments prescribe ancillary medications (e.g., metronidazole, metoclopramide, ondansetron, maropitant, and capromorelin oral solution) at the first treatment The growing interest in veterinary oncology prompted the 1st meeting of the Veterinary Cancer Society in 1976, with incorporation as a legal entity the next year. Additional innovation in veterinary chemotherapy followed. The 1st report of doxorubicin use in dogs was published in the veterinary literature in 1976

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With an increased interest in veterinary oncology in recent years, more and more general practitioners are administering and prescribing antineoplastic agents for their patients. In order to avoid unnecessary human exposure to these toxic agents, it is important to educate clinic employees and pet owners on how to safely handle antineoplastic drugs and animal waste [ While typically not as bad as the cancer these drugs are fighting against, these side effects can pack a wallop, and it is best if you and your vet talk about all the risks involved in any treatment. All that being said, here are are a couple of medications that can help manage your dog's condition. CHEMOTHERAPY. CeeNU (Lomustine

Chemotherapy VCA Animal Hospita

  1. CHEMOTHERAPY SAFTY FOR THE PATIENT 3. Drug Preparation; •Ensure that the drug ordered is the drug prepared, and that the total dose calculated is the dose that is drawn up. •Only one dose should be drawn up at a time •Check the appearance and integrity of the drug •There should only be ONE chemotherapy drug in the hood at a tim
  2. e receptors. This drug has the added benefit of stimulating motility of the upper GI tract without stimulating gastric, biliary, or pancreatic secretions
  3. istration, although concentrations are markedly decreased within the first 3 days. Many drugs are eli
  4. istration of small doses of cytotoxic agents. Goals: 1. anti-angiogenic effect 2. immunostimulatory effect. Term. name three indications for chemotherapy. Definition. 1. primarily indicated for systemic and metastatic neoplasms. 2. useful adjuvant treatment following incomplete excision
  5. Also, multiple drug resistance (MDR, pleotrophic drug resistance) may develop that allows a tumour to be resistant to a wide variety of drug types. Clinical End-Points . Once a patient is started on chemotherapy, there must be a clear method of evaluating the tumour response so that future treatment decisions can be made
  6. istration of Chemotherapy Drugs

With Rise in Chemotherapy for Pets, Higher Risks for

  1. Personal protective equipment or PPE is designed to protect employees from exposure to hazardous drugs. The type of PPE that is required depends on the specific task and risk of exposure. Types of PPE that are used in the handling of HDs include chemotherapy gloves, chemotherapy gowns, goggles, face shields, respiratory protection (fit tested.
  2. ister, with only five doses for a full treatment, and is generally well-tolerated in clinical studies. This canine lymphoma treatment is a convenient option for pet owners and clinics
  3. Anemia (low red blood cell count) is often a complication of cancer but is rarely caused by the chemotherapy drugs used in veterinary medicine. Hair follicle cell in dogs (and cats) that are wire-haired or non-shedding may be particularly susceptible to chemotherapy. Certain breeds of dogs, such as terriers and poodles, will experience variable.
  4. The majority of U.S. veterinary clinics consist of small teams of veterinarians who, if they don't refer cases to a specialist, are likely to provide chemotherapy regimens for their patients. Larger clinics often have a cancer specialist on staff who is well-educated about the proper handling of hazardous drugs and follows compliance.
  5. g observation was drawn up by the National Health Security Agency (ANSES), which recommended Tuesday to recognize in the law, the carcinogenic nature of occupational exposure to 18 chemotherapy drugs. They are more precisely substances called cytostatic, ad
  6. While the chemotherapy drugs used for both human and pet cancers are the same, the treatment experience is often drastically different, explains Kimberly Reeds, DVM, MS, DACVIM (Oncology), of Holland's Veterinary Referral Hospital in Oklahoma City. In humans, the goal of cancer treatment is to cure

Chemotherapy Guidelines - Veterinary Medicine at Illinoi

USP 800: Impact of New Regulations on Veterinary Hospitals

This means setting aside a room to be used exclusively for chemotherapy procedures. In specialty practices with oncology services, the room should be large enough to prepare and administer the drugs as well as segregate patients from common areas during hospitalization. The busy treatment area is the least suitable place for these procedures Carcinogenic Chemo Drugs. By Demian Dressler, DVM. Demian Dressler, DVM. Dr. Demian Dressler is internationally recognized as the dog cancer vet because of his innovations in the field of dog cancer management, and the popularity of his blog here at Dog Cancer Blog. The owner of South Shore Veterinary Care, a full-service veterinary. Veterinary Oncology Consultants 379 Lake Innes Drive Lake Innes, NSW 2446 Australia. voc@vetoncologyconsults.com +61 (2) 6585 3192. Veterinary Oncology Consultants respectfully acknowledge Australia's First Peoples, and that we live and work on Birpai Country. We pay our respect to the Elders from all Aboriginal nations, both past and present. A CTS system plays a vital role in the safe preparation of chemotherapy drugs by preventing any drug spills, over-pressurized vials, aerosolized drugs, and removing the risk of accidental needle punctures. A CTS also helps safeguard against accidently pressing the plunger and losing any amount of drug prior to administration Chemotherapy & Hazardous Drugs. Drugs are classified as hazardous if they may cause cancer, developmental or reproductive toxicity or harm to organs at low doses. They include drugs used for cancer chemotherapy (also called antineoplastics), antiviral drugs, hormones, some bioengineered drugs and other various drugs

Please give our team at Arizona Veterinary Oncology a call today at (480) 327-6690 to schedule an appointment to discuss what is best for your pet. Pet Chemotherapy drugs have the potential to cause damage to normal cells. Exposure to chemotherapy drugs or patient waste can pose a risk, despite the fact that the concentrations of drugs are very. for purchasing, receiving and storing cytotoxic drugs (currently the IVABS Veterinary Teaching Hospital purchasing officer). The refrigerator where the cytotoxic drugs are stored shall be labeled with a warning that cytotoxic drugs are held there and kept in the dispensary or designated oncology ward Chemotherapy is a term given to a group of drugs that have the ability to kill cancer cells in dogs. The specific medication or combination will depend on the type of cancer your dog has, as well as his overall health. Your vet will monitor the chemotherapy treatment to ensure that it is working well with minimal side effects Different types of lymphoma may be treated with different chemotherapy drugs. For instance, the most effective drug for cutaneous lymphoma is thought to be lomustine (CCNU) . The veterinary oncologists and oncology residents at the PUVTH will help you decide on a chemotherapy treatment protocol that is appropriate for your dog The typical side effects of injectable chemotherapy include adverse gastrointestinal signs, including vomiting, diarrhea, and/or poor appetite, and a temporary lowering of the recipient's white blood cell counts. These signs are the same potential consequences of oral medications as well. Veterinary oncologists typically quote a 20% chance.

Safety concepts for veterinary medicine | Berner SafetyCancer Chemotherapy and Cytotoxic Agents | Basicmedical Key

Safe handling of chemotherapy drugs - AAH

The most common TKI used in veterinary medicine is Palladia (Toceranib). For more information on Palladia please visit: www.mypalladia.com. Local (Intralesional) Chemotherapy. Local chemotherapy is the administration of chemotherapy directly into a tumor or into the surgical site after the tumor has been removed Side Effects of Vincristine. As with most other chemotherapy drugs, there are a few side effects associated with the use of Vincristine. The drug can interact with the pet's nervous system and can give rise to seizures and neurological disorders. Commonly seen symptoms include loss of hair and nausea. Some pets may also suffer from diarrhea

Treatments to treat cancers, which are themselves carcinogenic for caregivers. This alarming observation was drawn up by the National Health Security Agency (ANSES), which recommended Tuesday to recognize in the law, the carcinogenic nature of occupational exposure to 18 chemotherapy drugs. They are more precisely substances called cytostatic, administered in human and veterinary medicine b In 400 B.C., Hippocrates, the father of medicine, applied the term karkinos, meaning crab, to describe tumors and is the origin of the word cancer. 2. Since the earliest days, discoveries in veterinary oncology have generally paralleled human findings. A major breakthrough in cancer study came with the development of the microscope in 1590 Canine chemotherapy cost can be really high. However, dog owners can opt for another way to save some money on a typical canine chemotherapy. There are a number of studies going on to test the results of the various canine chemotherapy treatments and drugs held by some of the best veterinary teaching hospitals in the country Chemotherapy works with the cell cycle. Every time any new cell is formed, it goes through a usual process to become a fully functioning (or mature) cell. The process involves a series of phases and is called the cell cycle. Chemotherapy drugs target cells at different phases of the cell cycle. Understanding how these drugs work helps doctors. Targeted cancer therapies are drugs or other substances that block the growth and spread of cancer by interfering with specific molecules (molecular targets) that are involved in the growth, progression, and spread of cancer.Targeted cancer therapies are sometimes called molecularly targeted drugs, molecularly targeted therapies, precision medicines, or similar names

The Madison Wisconsin Chemotherapy Protocol (CHOP) is a multidrug rotational chemotherapy and the current standard of care in the treatment of canine lymphoma. Remission duration with CHOP therapy depends on which type of lymphoma a dog has. B-cell lymphoma has an average remission of nine or 10 months and T-cell four to five months with CHOP. Veterinary Oncology Consultants respectfully acknowledge Australia's First Peoples, and that we live and work on Birpai Country. We pay our respect to the Elders from all Aboriginal nations, both past and present, and to those Elders who are yet to come; and their continuing cultures and contributions The current situation in the use of antiviral drugs in veterinary medicine is characterised by a novel and optimistic approach.Viruses of veterinary importance are still used as animal models in the developmentof human therapeutics, but there is growing interest in many of these viruses in the identification of antiviral molecules for use in both livestock and companion animals Cancer Chemotherapy for the Veterinary Health Team is a clinically relevant and practical manual designed as a guide for the safe and effective administration of cancer chemotherapy. Coverage includes patient assessment, chemotherapy equipment, drug preparation, safety considerations, handling, administration, waste disposal, and management of chemotherapy side effects Three Tips for Compliant Veterinary Medical Waste Disposal. To avoid hefty fines, it's vital that veterinary clinics find compliant and affordable veterinary medical waste disposal services. For those that generate only a small amount of infectious waste, we find the best, and cheapest, way to do this is by using a medical waste mail back system

A cancer drug that benefits people may soon benefit man's best friend. Kim Selting, assistant teaching professor of oncology at the MU College of Veterinary Medicine, is the principal investigator in a study that examines the efficacy of Attaxol™ in dogs with naturally occurring cancer. Attaxol™ was developed, and is produced, by CritiTech, a Lawrence, Kan. drug development company Acces PDF Cancer Chemotherapy A Veterinary Handbook Cancer Chemotherapy A Veterinary Handbook Thank you very much for downloading cancer chemotherapy a veterinary handbook.Maybe you have knowledge that, people have look numerous period for their favorite books when this cancer chemotherapy a veterinary handbook, but stop in the works in harmful downloads Increased dose intensity is achieved by increasing the doses of the individual chemotherapy drugs in a protocol; dose density is increased by decreasing the time interval between doses. A recent report of a dose-intense, CHOP-based protocol for canine lymphoma reported similar response and outcome but higher toxicity when compared to previously. Chemotherapy refers to a variety of different medications that are used in dogs or cats that have aggressive cancers or cancers involving multiple sites in the body. Our board-certified specialists use the same chemotherapy drugs that are used to treat human cancer patients A Comparative Oncology Drug Discovery Pipeline to Identify and Validate New Treatments for Osteosarcoma Cancers (Basel) . 2020 Nov 11;12(11):3335. doi: 10.3390/cancers12113335

Answer: Oncology is a growing specialty area of veterinary care and there are private practices and veterinary schools offering this service throughout most areas of the USA. In some areas this may involve considerable distances to travel to seek out specialty care. Your veterinarian can call specialists at these schools and practices on your behalf to ask about what the best treatment option. 1.800.399.VETS | 1301 NW 84th Ave Suite 101A, Miami, FL 3312

Some chemotherapy drugs are used for many different types of cancer, while others might be used for just one or two types of cancer. Your veterinarian recommends a treatment plan based on: • The type of cancer your dog has. • The part of the body the cancer is found. • The effect of cancer on the dogs normal body functions Center for Veterinary Medicine. This guidance document makes recommendations to sponsors of investigational oncology drugs for use in companion animals (e.g., dogs, cats, and horses). The guidance.

Veterinary Article: Chemotherapy in Veterinary Medicine by

Chemotherapy is the cornerstone of treatment for many types of veterinary cancer. Our chemotherapy protocols are designed to maintain a pet's excellent quality of life while providing the most effective therapy against cancer. All chemotherapy appointments include physical examinations performed by the oncologist, blood work evaluation to. NIOSH recently conducted a health hazard evaluation of a veterinary specialty hospital in response to concerns about possible occupational exposures to chemotherapy drugs. Agency staff assessed whether work surfaces were contaminated by sampling surfaces in the chemotherapy administration area after drugs were administered As veterinary medicine advances and better technology is made available, pet cancer treatments are more effective than ever. Chemotherapy Powerful drugs are used to destroy or damage cancer cells, particularly blood-cell cancers such as lymphoma and leukemia, and cancers that have spread (metastasized) or are likely to.. Chemotherapy is widely used in veterinary practice. 70.8% of respondents reported using cytotoxic chemotherapy for the treatment of cancer in one study. Yet, how many practices apply appropriate measures for handling cytotoxic drugs or the patients who receive them

Although some of these drugs are in the earlier stages of development, they hold strong potential and are becoming clinically available for patient care. Veterinary oncology thera­peutics of interest in the United States, regulated by either the FDA or the US Department of Agriculture (USDA), are summarized in the Table Your vet will more than likely choose the best combination of feline cancer treatments while considering your cat's quality of life. A combination of treatments is usually more effective than using just one type. For example, doses of several different chemotherapy drugs make it less likely that your cat's cancer will become resistant to one drug For any intravenous (IV) chemo drugs, find out if the drug is available in pill form that you can give at home rather than having IV treatment at the clinic. Chemotherapy III Check prices of the chemotherapy agents. Often, you'll find that you purchase them (with a prescription from your vet) from a pharmacy at a lower price. Cut Costs for Surger The cytotoxic drugs will be sent to a person who has been deemed competent for purchasing, receiving and storing cytotoxic drugs (currently the IVABS Veterinary Teaching Hospital purchasing officer). Cytotoxic drugs will be stored in a separate refrigerator in the dispensary or designated oncology ward Chemotherapy drugs containing platinum, like cisplatin or carboplatin, can be detected in a patient's urine for up to 5 days. The veterinary cancer patient presents additional concerns about waste. Since pets rarely use toilets, there is increased potential for direct exposure to humans and other animals

Overview of Chemotherapeutics - Merck Veterinary Manua

Canine Lymphoma Chemotherapy. Chemotherapy is the general name for conventional drug treatments that seek to poison the rapidly growing malignant cancer cells, while at the same time causing the least amount of harm to the other healthy cells in the patient's body. Because of the systemic nature of Canine Lymphoma (with cancer cells generally. In chemotherapy patients with MDR1 gene mutation, p-glycoprotein expression is reduced or absent leading to increased intracellular drug concentrations and haematological and gastrointestinal toxicity. A number of breeds are predisposed to this mutation, particularly herding breeds such as Collies, Border Collies, Shetland Sheepdogs, Australian. Veterinary hospital employees were concerned about adverse health effects from the use of chemotherapy drugs in the oncology department. In 2004, NIOSH released an Alert regarding occupational exposures to antineoplastic and other hazardous drugs that are used in health care settings Multimodal therapies combining pain control, radiation and chemotherapy can be used to provide comfort and ease suffering of patients even in the most advanced stages of their disease. <HOME> Karen Oberthaler, VMD, Dipl. ACVIM (Oncology), is a medical oncologist at NYC Veterinary Specialists and Cancer Treatment Center

J Vet Internal Med 13 395-398, 1999. 4. Rassnick KM, Mauldin GE, Al-Sarraf R, Mauldin GN, Moore AS, and Mooney SC. MOPP chemotherapy for treatment of resistant lymphoma in dogs: a retrospective study of 117 cases (1989-2000) J Vet Internal Med 16, 576-580, 2002. 5 hazardous drugs (2014, or most recent edition), the majority of which are chemotherapy drugs. Note: The Medical Centers have developed their own guidelines and procedures for handling chemotherapy/hazardous drugs. The guidelines in this document focus on use in research settings Exposure to chemotherapy drugs for a long period of time may represent a hazard for those who administer or handle the drugs. Little is known about the potential harm, if any, to those who care for a pet that is receiving chemotherapy. Carefully following safety precautions will minimize risks associated with chemotherapy. Handling Chemotherapy.

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J.L. Demetriou, in Feline Soft Tissue and General Surgery, 2014 Surgery in combination with chemotherapy and/or radiotherapy. Over the past few years in veterinary oncology there has been a drive to treat cancer patients using a multidisciplinary approach. This includes using surgery followed or preceded by either (or both) chemo­therapy, radiotherapy or immunotherapy Although not a chemotherapy drug in the traditional sense, it is still important to take appropriate precautions when administering Palladia tablets. Tablets should not be broken or crushed, and latex gloves should always be worn when handling the tablets. Palladia tablets can be given in a Pill Pocket or food These drugs are usually used in combination with chemotherapy and/or radiation therapy, but may occasionally be used alone. What is the prognosis? Osteosarcoma is not a curable cancer, however it is treatable. Local disease control in combination with systemic chemotherapy can give your pet many months to years of good quality life

Staff Competency Program for Chemotherapy Preparation

ACVIM small animal consensus statement on safe use of

L-Asparaginase is a chemotherapy drug that is used in veterinary medicine to treat cats and dogs that are suffering from certain types of cancers known to affect the immune system, but predominantly to treat lymphoma. All cells need asparaginase to produce protein In veterinary chemotherapy, Piroxicam can be used to reduce the necessary dosage of Methotrexate, a drug used to treat certain types of lymphoma. It also can be combined with opioid analgesics to reduce discomfort in oncology patients, while reducing the drowsiness commonly associated with those drugs Palladia is a prescription chemotherapy drug used to treat mast cell tumors. The drug in Palladia is Toceranib. Why do dogs use Palladia? Palladia is prescribed to treat Patnaik grade II or III, recurrent, cutaneous mast cell tumors with or without regional lymph node involvement in dogs. What else should I know about Palladia

Safety and handling of chemotherapeutic agents BSAVA Librar

a The mean time on study during the masked phase was 37.0 days for PALLADIA-treated dogs (median, 42.0 days) and 27.6 days for placebo-treated dogs (median, 21.0 days); no adjustments were made in the statistical comparisons for this disparity.. b Investigators assigned severity grade of 1, 2, 3 or 4 (1 - least severe; 4 - most severe).. c Grading of laboratory abnormalities was based on the. In this VETgirl online veterinary continuing education blog, guest blogger Dr. Kristen Kicenuik from Hope Veterinary Specialists reviews how to safely give chemotherapy in veterinary medicine to your canine and feline oncology patients. Learn to be safe when administering chemo in dogs and cats In pets, chemotherapy is aimed at controlling the disease and achieving a period of remission. Chemotherapy is typically used for cancers that affect multiple sites. Lymphoma is the most common form of feline cancer that is treated with chemotherapy. The drugs used in veterinary chemotherapy are frequently the same drugs used in human medicine

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ChemochekTMChemotherapy Training is a self-administered, hands-on techniques training to safely handle chemotherapy drugs. Programs such as these can be a valuable tool to practice drug handling techniques which reduce occupational exposure. VHUP Drug Preparation. Avoid all skin contact with hazardous drugs with an intravenous chemotherapy drug called mitoxantrone. In a study performed by the Veterinary Cooperative Oncology Group, this combination treatment resulted in a remission rate of approximately 35%. In addition to dogs that had remission, 46% of the dogs also had stable disease where the cancer did not grow for a period of time Sarah Wetzel, a WSU oncology resident, administers capecitabine to Rollie by sneaking it in his food at the WSU Veterinary Teaching Hospital. Rollie is the first patient enrolled in a clinical study examining the drug's efficacy in treating carcinomas in dogs